CRP and obesity due to melanocortin 4 receptor deficiency: If there are other diseases present (such as cardiovascular disease, obesity, sepsis-induced coagulopathy score > 4, high D-dimer (>6 times the normal), C-reactive protein (CRP), troponins, and other symptoms of disseminated intravascular coagulation) [26], hospital mortality for patients with severe COVD-19 can increase to 42%.