This highlights the role of PP2A as a tumor suppressor which is further supported by the report that PP2A inhibits the protein synthesis of oncogenes such as induced myeloid leukemia cell differentiation protein (MCL1) and c-MYC through dephosphorylation of eukaryotic translation initiation factor 4E (EIF4E) by inhibition of MAPK interacting protein kinases 1 and 2 (MNK1,2 kinases) [22]. This evidence concerns the gene EIF4E and neoplasm.