POMC and pituitary tumor: Since PRKCD is down-regulated in human ACTH-secreting pituitary tumors and it was proven to be involved in the control of cell viability as well as POMC and ACTH expression in AtT20/D16v-F2 cells [6, 10], we explored PRKCD role in mediating Pasireotide effects in AtT20/D16v-F2 cells over- or under-expressing PRKCD.