GSEA was performed to compare the differences in enriched signaling pathways between the high- and low-risk groups, and the results suggested that seven signaling pathways were enriched in the high-risk group, including ABC transporters, TGFβ signaling pathway, dorsoventral axis formation, ERBB signaling pathway, glycerolipid metabolism, long-term depression, and maturity onset diabetes of the young (|NES|> 1, NOM p < 0.05, Fig. 5a). This evidence concerns the gene ABCG2 and type 2 diabetes mellitus.