Nrg1 TM HET mice are more susceptible than WT controls to effects of stress on schizophrenia-relevant behaviours (Chesworth et al. 2012b), and individuals carrying an NRG1 variant who experience stressful life events are more likely to use alcohol, tobacco and illicit drugs than to individuals who do not carry the NRG1 variant (Vaht et al. 2017). The gene discussed is NRG1; the disease is schizophrenia.