Nrg1 TM HET mice exhibit cognitive deficits in novel object recognition and recall of contextual fear conditioning (Duffy et al. 2010), while in clinical populations, NRG1 SNPs and serum NRG1β1 concentration are linked with poorer cognitive ability in individuals with schizophrenia (Cho et al. 2015; Yang et al. 2021). This evidence concerns the gene NRG1 and Cognitive impairment.