Furthermore, the hypomethylation of HIST1H3I (Histone linker 1 with Histone H3.1), HIST1H3D (Histone linker 1 with Histone H3.D), NFATC4 (Nuclear factor of activated T-cells cytoplasmic 4) and HOXB8 (Homeobox B8) and increase in their oncogene functions was associated with colon cancer and increased adiposity [146]. The gene discussed is HOXB8; the disease is colonic neoplasm.