A combination of oral quercetin and dasatanib in patients with obesity, diabetes and CKD resulted in significantly reduced numbers of SAT β-galactosidase positive senescent adipocytes (−62%), SAT CD68+ macrophages (−28%) and SAT CLS (−86%), as well as circulating plasma SASP factors (IL-1α, IL-2, IL-6, IL-9, MMP-2, MMP-9, MMP-12). The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.