Our analysis of Kaplan–Meier plots derived from data on 1925 lung cancer patients clearly confirmed the strong oncogenic role of HK2, LDHA, PHGDH, PSAT1, SHMT2, MTHFD2, c-Myc, and ATF4 (CREB-2) in lung cancer. The gene discussed is MTHFD2; the disease is lung carcinoma.