Lactate accumulation in the tumor microenvironment promotes immunosuppression by inducing histone lactylation in tumor-infiltrating myeloid cells, thus upregulating methyltransferase-like 3 [2]; additionally, lactate-induced histone lactylation in melanoma promotes YTH structural domain family protein 2 expression, thus driving tumorigenesis [3]. Here, METTL3 is linked to neoplasm.