However, according to previous data retrieved from a proteomics and miRNA profiling analysis in a total of 1157 subjects without baseline T2DM from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort, it has been documented that endocan might even be a prognostic marker of the decline in β-cell function and the development of impaired glucose tolerance and T2DM [44]. Here, INS is linked to type 2 diabetes mellitus.