INS and pancreatitis: The only randomized clinical trial comparing plasma exchange with insulin infusion in mild hypertriglyceridaemia-induced pancreatitis failed to demonstrate the superiority of either modality in rapidly reducing TG levels or clinical outcomes [97] Similarly, high-volume haemofiltration has produced a significantly greater reduction in TG at 24 h; however, it was not found to yield superior clinical outcomes, that were comparable with insulin infusion despite a greater proportion of insulin infusion recipients having APACHE II scores ≥8 (67% (n = 34) vs. 53% (n = 32)) [98].