HIF1A and cancer: Fructose diphosphatase (FBP) can not only regulate the glucose/glycogen synthesis of carbohydrate precursors but can also interact with proteins (such as ATP synthase, HIF1-α and NF-κB) to influence cell-cycle-dependent events, mitochondrial biogenesis and membrane polarization, expression of glycolytic enzymes, induction of synaptic plasticity, and even cancer progression [63].