Hu et al. found that a model that included age, male gender, left ventricular ejection fraction, hypertension, hemoglobin, serum UA concentrations, hypomagnesemia, use of oral renin–angiotensin system inhibitors, and the use of non-steroidal anti-inflammatory drugs within 1 week before surgery predicted the development of postoperative AKI with an AUC of 0.740 [40]. The gene discussed is REN; the disease is acute kidney injury.