In the VAT of the Ob + Pre-T2D group, GIP (100 nM) stimulation increased pyruvate consumption (Ob + Pre-T2D: GIP (0 nM), 2.20 ± 0.04 nmol/mg of VAT vs. GIP (100 nM), 2.46 ± 0.03 nmol/mg of VAT, Δ 11.69%, p < 0.01). Here, GIP is linked to type 2 diabetes mellitus.