SPARC, due to its various properties, might constitute an efficient therapeutic tool, since it acts on various levels (Figure 1) that would allow it to tackle health problems related to COVID-19 severe-form risk factors, as well as public health problems during the post-COVID-19 era, and to help COVID-19 patients both during hospitalization and in the management of long COVID-19 (complications following acute illness). The gene discussed is SPARC; the disease is COVID-19.