ABCB1 and cancer: 2-Aminoimidazole marine alkaloids have various biological activities, including anti-cancer [12], antimicrobial [13,14], antivirus properties [15], ABCB1-mediated MDR reversal activity [16] as well as both leukotriene B4 receptor [17] and epidermal growth factor (EGF) receptor antagonist activities [10].