HIF-1α may activate the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, VEGFs (vascular endothelial growth factors) and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia, as well as promoting angiogenesis, tumor invasion and metastasis, and resistance to therapy [45]. Here, HIF1A is linked to neoplasm.