COL2A1 and osteoarthritis: This study suggests that using PVA-CS nanofiber scaffolds had a promoting effect on chondrogenic differentiation of ADSCs, as demonstrated by significant upregulation of aggrecan and collagen type II alpha 1 Chain (COL2A1), suggesting PVA-CS-ADSCs nanofiber scaffolds can potentially be used to improve the pathophysiology of osteoarthritis (OA).