In this study, the effects of T. lutea F&M-M36 on the main components of pre-MetS, blood lipids, glucose, pressure, and inflammation were investigated; furthermore, since T. lutea is rich in DHA [8], a natural ligand of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα), its effects were compared to those of fenofibrate, a synthetic ligand of the same receptor currently used in the pharmacotherapy of dyslipidemia [10]. The gene discussed is PPARA; the disease is metabolic syndrome.