PPARA and early-onset autosomal dominant Alzheimer disease: Among up-regulated pathways, it is of interest to mention PPAR signaling and Huntington’s, Parkinson’s, and Alzheimer’s disease pathways since they include several electron transport chain and oxidative phosphorylation genes (several ATP synthases (ATPs, cytochrome c oxidases (COXs), and NADH ubiquinone oxidoreductases (Ndufs)) and peroxisome proliferator-activated receptor gamma (PPARγ).