Furthermore, frondoside A is shown to result in a concentration-dependent decrease in the viability of hepatoma cells (HepG2) and lung cancer cells; LNM35, A549, and NCI-H460-Luc2, breast cancer cells (MCF-7), and melanoma cells (MDA-MB-435) over 24 h, and elevated the activities of caspases-3 and -7 in LNM35 lung cancer cell [64]. The gene discussed is CASP3; the disease is lung cancer.