Our previous studies have found that polymannuroguluronate sulfate (PMGS), which is a sulfated polysaccharide synthesized from marine alginate derived from brown seaweed [10,11], possesses robust anti-HPV activities in vitro and in vivo, alleviates leukopenia caused by chemotherapy, promotes the differentiation and maturation of CD4+ T cells in the thymus, inhibits the apoptosis of CD4+ T cells [10], and inhibits the expressions of E6 and E7 genes [11]. This evidence concerns the gene CD4 and Decreased total leukocyte count.