VCAM1 and sexually transmitted disease: Microglia are the major inflammatory cells in the central nervous system, and their mediated neuroinflammation plays an important role in VD.[55] SRC kinase (SRC) plays a key role in triggering microglia activation and is a key factor involved in the development of neuroinflammation.[56] In addition, both pro-inflammatory cytokines and vascular endothelial dysfunction can induce overexpression of vascular cell adhesion molecule 1 (VCAM1).