Quercetin, luteolin, kaempferol, and ginkgolide B are the key active ingredients of GBLs against VD and act on multiple signaling pathways, such as PI3K/Akt, lipid and atherosclerosis, fluid shear stress, and atherosclerosis through the regulation of AKT1, TNF, IL6, VEGFA, IL1B, and other targets, among which the PI3K/Akt signaling pathway seems to play a key role. The gene discussed is TNF; the disease is atherosclerosis.