TNF and atherosclerosis: Removing signaling pathways containing specific diseases, KEGG pathway analysis showed high target enrichment in lipid and atherosclerosis, the PI3K/Akt signaling pathway, fluid shear stress and atherosclerosis, the AGE–RAGE signaling pathway in diabetic complications, the TNF signaling pathway, the HIF-1 signaling pathway, apoptosis, and the endocrine resistance signaling pathway.