Pro-inflammatory mediators, including IL-8, can induce NETosis.[91] severe acute respiratory syndrome coronavirus 2 also activates platelets, which can also induce NETosis.[92] Patients with COVID-19 have a higher number of low-density granulocytes, which can cause NETosis.[93] Zuo Y and his colleagues[31] found higher levels of cytosolic free DNA, MPO-DNA, and guanylate histone H3 in the serum of COVID-19 patients, they also found that serum from COVID-19 patients induced NET release from normal neutrophils in vitro. This evidence concerns the gene MPO and COVID-19.