Indeed, active sliding of integrin α5β1 and Tensin1 bound to FN along central actin stress fibers increases traction forces (Georgiadou and Ivaska, 2017; Pankov et al., 2000) and is required in cell migration during development and cancer metastasis (Efthymiou et al., 2020; Schwarzbauer and DeSimone, 2011). This evidence concerns the gene FN1 and cancer.