VEGFA and angiosarcoma: Amplification of MYC gene, which codes for a transcription factor, has been reported to be present in cases of secondary angiosarcoma [32,33]; Guo et al. hypothesized that Fms-related tyrosine kinase (FLT4), encoding a tyrosine kinase receptor for vascular endothelial growth factors, may be a potential candidate for this gene amplification [34].