NGF and astrocytoma (excluding glioblastoma): In 1321N1 human astrocytoma cells, hericenones C, D and E from the H. erinaceus sporophore, failed to promote NGF gene expression [82], while only isolated hericenone E, among all the present hericenones, was able to stimulate NGF-mediated neurite outgrowth via the MEK/ERK and PI3K-Akt signaling pathways in PC12 cells [83].