An immunoproteomic approach has shown that some S. brasiliensis peptides (ZR8 and ZR3) stimulate the production of INF-γ, IL-1β, and IL-17A in CD4+ T cells, demonstrating that these peptides may be candidates for a possible vaccine against sporotrichosis, especially that caused by the zoonotic route [122]. The gene discussed is CD4; the disease is sporotrichosis.