IL6 and peripheral arterial disease: In fact, another study looking at limb vascular inflammation by measuring the transfemoral gradients of neutrophil myeloperoxidase (MPOx) content and interleukin-6 (IL-6) found that the coexistence of PAD did not necessarily imply a more severe coronary atherosclerosis in patients with CAD, and only those with an inflammatory status of the affected limb presented a more severe CAD [47].