INS and staphylococcus aureus infection: The down-regulated pathways in the NS versus LS group included “PI3K-Akt signaling pathway” (1.49%), “Protein digestion and absorption” (1.16%), “Insulin resistance” (0.82%), “Complement and coagulation cascades” (0.07%), and “Staphylococcus aureus infection” (0.03%) (Table S7).