ALK and non-small cell lung carcinoma: Three randomized clinical trials have confirmed the good performance of pemetrexed in ALK+ NSCLC, both in the second-line setting (PROFILE-1007) and in the first-line setting (PROFILE-1014 and ASCEND-4): in the second-line setting, the overall response rate (ORR) to pemetrexed was 29% with a median-progression-free survival (mPFS) of 4.2 months; in the first-line setting, the ORR was 27–45% with a mPFS of 7.0–8.1 months [28,29,30].