It was designed to compare crizotinib versus first-line chemotherapy (cisplatin or carboplatin plus pemetrexed) in 343 patients with advanced ALK+ (as determined centrally with the use of a Vysis ALK Break Apart FISH Probe Kit) non-squamous NSCLC who had not received previous systemic treatment for advanced disease [29]. This evidence concerns the gene ALK and non-small cell lung carcinoma.