The genotype polymorphism IL-1RN (VNTR), in recent studies, has shown no clear association with the increased risk of PID [56], although functional genetic polymorphisms of IL-1β (+3954) and IL-1RN (VNTR) may diversify IL-1β and IL-1RA protein production, thus affecting inflammation and causing implant failure [56,61]. The gene discussed is IL1B; the disease is pelvic inflammatory disease.