The examples affecting osteosarcoma cells are axes lncRNA CASC2—miR-181a—RASSF6 [81], PTEN and ATM, lncRNA-p21—miR-130b and PTEN [82], lncRNA NBAT1—miR-21—PTEN, PDCD4, TPM1, and RECK [83]. Here, PTEN is linked to osteosarcoma.