AKT1 and posterior cortical atrophy: The inducible HO-1 exhibits anticancer inhibitory effects mediated by CO, bilirubin, and Fe+2 metabolic products via the activation of multiple signaling pathways, including kinase pathways PI3K/Akt, MAPKs, Nrf2/ARE, ERK1/2, and Akt/mTOR, and ferroptosis induction, and the upregulation of apoptotic proteins, which neutralize oxidative stress, can lead to the inhibition of PCa proliferation and the induction of apoptosis (Figure 1).