Since anti-inflammatory and anticarcinogenic drugs have the ability to activate the Nrf2/ARE/electrophile-responsive element (EpRE) cytoprotective pathways while inhibiting NF-κB signaling, alpha tocopheryl succinate (α-TOS)-induced ROS production affected the upregulation of Nrf2-driven genes leading to the suppression of NF-κB in the PCa cell line [4]. This evidence concerns the gene NFE2L2 and posterior cortical atrophy.