BRCA1 upregulates HO-1 expression in LNCap, PC3, 22RV1, and C4-2 PCa cell lines and Nrf2 cooperates with the BRCA1 protein to activate the HO-1 gene, suggesting a new mechanism for the maintenance of cellular homeostasis in PCa [46]. Here, HMOX1 is linked to posterior cortical atrophy.