Jayasooriya et al. show that CPT inhibited DU145 PCa cell proliferation and invasion by suppressing the NF-kB pathway and inhibiting NK-kB and pi3k/Akt activity, resulting in MMP-9 and VEGF overproduction, subsequently upregulating Nrf2-mediated HO-1 induction [68]. Here, AKT1 is linked to posterior cortical atrophy.