The inducible HO-1 exhibits anticancer inhibitory effects mediated by CO, bilirubin, and Fe+2 metabolic products via the activation of multiple signaling pathways, including kinase pathways PI3K/Akt, MAPKs, Nrf2/ARE, ERK1/2, and Akt/mTOR, and ferroptosis induction, and the upregulation of apoptotic proteins, which neutralize oxidative stress, can lead to the inhibition of PCa proliferation and the induction of apoptosis (Figure 1). This evidence concerns the gene NFE2L2 and posterior cortical atrophy.