This finding is in line with recent evidence from molecular and cellular studies reporting abnormalities in a series of autophagic genes, such as AMPK, ULK1, AKT, MTOR, and BECN1, that block several steps of the autophagic process, some of which were reported as being relevant in the development of MDSs and their transformation to AML [16]. This evidence concerns the gene AKT1 and acute myeloid leukemia.