Interestingly, TSC1 GFAP CKO and TSC2 GFAP CKO mice had no significant differences in Glt1 expression, but the TSC2 GFAP CKO had an earlier onset of epilepsy, a higher seizure frequency, and earlier mortality than TSC1 GFAP1 CKO mice. This evidence concerns the gene TSC2 and epilepsy.