As the name suggests, the TNF-α was originally identified as a factor produced from activated T-lymphocytes, macrophages, and natural killer cells which can cause necrosis of the tumor cells; however, it has now been found to have a pleiotropic action mechanism that can influence various signal transduction pathways related to cell survival and death in addition to immunological cascades [34]. The gene discussed is TNF; the disease is neoplasm.