This study has investigated the influence of promoter SNPs in apoptosis genes that included Bax-248G>A (rs4645878)/ Bcl-2-938C>A (rs2279115) and pro-inflammatory cytokines including TNF-α rs1800629 G>A/ IL-8 rs4073 T>A on hematological cancers that include CML and other MPDs, and hence, determine the significance of such polymorphic variations in the risk of myeloproliferative disorders and their role as prognostic markers in disease management. Here, TNF is linked to myeloproliferative disorder.