Furthermore, we observed significant differences in the frequencies of IL-8 rs4073 T>A between leukaemia patients and healthy controls (p < 0.0001), with patients having higher frequencies of A allele (0.75 vs. 0.61) and AA genotype, while healthy individuals had higher frequencies of the TT genotype and T allele, indicating their protective effect against the disease. The gene discussed is CXCL8; the disease is leukemia.