Previously, others had explored a subset of neural antibodies (NMDAR1, AMPAR1, AMPAR2, GABABR1, GABABR2, CASPR2, LGI1, and DPPX) in 32 dogs with CNS disease, including four dogs with epilepsy, with a commercially available CBA expressing human antigen and indirect immunofluorescence assay, with postulated AB specificity because of high homology of the amino acid sequences between humans and dogs.20 The gene discussed is LGI1; the disease is epilepsy.