The density of infiltrating TANs is negatively related to the tumor differentiation in the lung adenocarcinoma.34 High infiltration of CD66b+ TANs is obviously associated with well differentiations in gastric cancer.18 Whether the low-level TANs in poorly differentiated tissues in this study is related to the anti-immunity and immune tolerance caused by CD163+ TAMs and FoxP3+ Tregs still needs further research to determine. The gene discussed is CEACAM8; the disease is lung adenocarcinoma.