Immune cell and inflammatory cell infiltration are mostly used in the prognosis prediction of various tumors, but the relationship between tumor cell differentiation and immune cell infiltration is not very clear.18,21,22 In this study, the infiltration of FoxP3+ Tregs, CD163+ TAMs, and CD66b+ TANs in CRC tissues was studied using tissue microarray and immunohistochemistry. This evidence concerns the gene CD163 and neoplasm.