CEACAM5 and colorectal carcinoma: Another study found that in patients with CRC, high carcinoembryonic antigen level and lymphovascular invasion factors and in patients with rectal cancer, factors including liver metastasis and venous invasion were identified as risk factors for recurrence.16 Yazilitas et al17 investigated the relationship of pathological and clinical features with time to recurrence in patients with early-stage CRC, identifying that grade I and superficial tumors (T1-T2) are predictors of late recurrence.