ESRRG and chronic kidney disease: In humans, mutations in or decreased expression of ERRγ have been linked to incidence of congenital anomalies of the kidney and urinary tract (CAKUT) and chronic kidney disease (CKD) (Berry et al., 2011; Eichner and Giguère, 2011; Harewood et al., 2010; Hock and Kralli, 2009; Misra et al., 2017; Zhao et al., 2018).