Furthering the involvement of MrgprB2-mediated signaling in MCs in headache, Compound 48/80, an agonist specific to MrgprB2, has long been used to induce migraine-like pain behavior in rodents, leading to mechanical sensitivity and light aversive behavior.55,56 Although MrgprB2 may possess direct involvement in inflammatory pain, additional in vivo studies and further clinical research of human homologue MrgprX2 are warranted to ascertain if it can be an effective new target for migraine pain treatment and future drug development for clinical use. The gene discussed is MRGPRX2; the disease is Headache.