Specifically, from the perspective of glycosylation-related enzymes, Peneff et al. found that uridine diphosphate-N-acetylglucosamine pyrophosphorylase-1 (UAP1), which can catalyze the synthesis of UDP-GlcNAc, and in glioma, the expression of its paralog UAP1L1 was significantly upregulated and closely related to poor prognosis [78]. This evidence concerns the gene UAP1L1 and central nervous system cancer.