Chong et al., on the other hand, showed for the first time how ST3GAL1 sialyltransferase is triggered by the TGF-β signaling pathway in a cohort of mesenchymal patients and regulates glioma formation by targeting degradation of the Forkhead box M1 (FoxM1) protein through anaphase-promoting complex/cyclosome (APC/C-Cdh1) [117]. This evidence concerns the gene FOXM1 and central nervous system cancer.