Compared with the KC-CM group, knockdown of PRTN3 expression in KCs (KCPR3KD-CM) attenuated heat stress-induced HCC cell proliferation, whereas overexpression of PRTN3 in KCs (KCPR3OE-CM) promoted heat stress-induced HCC cell proliferation (p < 0.01, Figure S9). This evidence concerns the gene CALCA and hepatocellular carcinoma.