Based on the AnimalTFDB and PlantTFDB databases, the DEPs were members of fourteen transcription factor families (Fig. 4F and Table S4), some of which were previously demonstrated to participate actively in the progression of HCC (e.g., bHLH, ETs, HMG_box, IRF, Myb, and HSF). This evidence concerns the gene CXCL2 and hepatocellular carcinoma.