In some clinical situations (e.g., leukemia and Wegener’s disease), PRTN3235, one peptide epitope, is recognized by CD4+ T cells and Tregs in immune responses against PRTN3 as a naturally processed HLA-class-II-epitope; this peptide is also recognized by dendritic cells in the blood of healthy individuals [40]. This evidence concerns the gene CD4 and leukemia.