MPO and hepatocellular carcinoma: To further understand the molecular mechanisms of PRTN3 in HCC and adjacent tumor tissues, we used the HCCDB database to conduct a gene expression interaction network analysis (Figures S7B-C) and found that the MPO-PRTN3 signaling pathway was activated in the three PPI network analyses, revealing the potential protumor role of these components as neutrophil protease genes.