SERPINA1 and hyperinsulinemic hypoglycemia, familial, 4: Several successful genetic mouse models have been used to validate the use of cell transplantation to treat inborn errors of metabolism (IEM) of the human liver, including albumin-uPA transgenic mice, mice with alpha-1-antitrypsin deficiency, and those with fumaryl acetoacetate hydrolase deficiency (familial tyrosinemia) [33–35].