For example, in a study conducted by Enrico Di Stacio et al. on 145 primary hyperparathyroidism patients who underwent parathyroidectomy using Minimally Invasive and Video-assisted methods, the time of 20 min was introduced as the endpoint for determining the success of parathyroidectomy using Io-PTH [21]. The gene discussed is PTH; the disease is primary hyperparathyroidism.