According to current reports, SOCS2, Snail, RDM1, and non-coding RNA LINC00958, etc. are all target genes of METTL3 in HCC; METTL3 could affect proliferation, migration, invasion and lipogenesis to facilitate HCC progression by regulating these target genes [15, 37–39]. This evidence concerns the gene SOCS2 and hepatocellular carcinoma.