STAT3 and hepatocellular carcinoma: The efficiencies of knockdown and overexpression were verified, as shown in Fig. 7A. The wound healing and transwell assays showed that METTL3 knockdown effectively inhibited the migration and invasive capacities of HCC cells, while overexpression of STAT3 countered the METTL3 depletion-induced inhibitory effect (Fig. 7B-F).