Tumors display aberrantly high O-GlcNAcylation [40], a result of Warburg Effect glucose uptake and the hyperglycemic tumor microenvironment because ca. 2–5% of cellular glucose is converted by the hexosamine biosynthetic pathway to the OGT sugar substrate UDP-GlcNAc (uridine diphosphate-N-acetylglucosamine) [41–43]. Here, OGT is linked to neoplasm.