OGT and cancer: There is a growing association between O-GlcNAc protein modifications and enhanced cancer progression [40, 44, 45], but our mechanistic understanding of O-GlcNAc-driven tumors remains far from solved because over 7000 proteins are known to be O-GlcNAc modified and OGT is the single enzyme responsible for all protein O-GlcNAc modifications [46, 47].