VWF and endothelial dysfunction: The study also found that levels of sTM and vWF in the plasma of the patients with T2DM were higher than in the control group, and the levels of sTM and vWF in the T2DM + PE group were higher than in the T2DM group, indicating that patients with T2DM have endothelial function damage before vascular lesions and endothelial dysfunction was further aggravated in patients with T2DM + PE.