The results showed that the levels of IL-1β and TNF-α in GCF of the subjects showed statistically significant differences among the three groups (P < 0.05), while the obesity group was the highest (IL-1β:75.69 ± 11.81ng/ml; TNF-α:7.26 ± 1.90ng/ml), followed by the overweight group (IL-1β:53.69 ± 8.21ng/ml; TNF-α:6.50 ± 1.21ng/ml), and the normal body weight group was the lowest (IL-1β:39.97 ± 6.10ng/ml; TNF-α:5.56 ± 0.98ng/ml). Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.