CRP and obesity due to melanocortin 4 receptor deficiency: While the levels of CRP in serum of the subjects showed statistically significant differences among the three groups (P < 0.05), while the obesity group was the highest (3.15 ± 0.37 μg/ml), followed by the overweight group (2.67 ± 0.41 μg/ml), and the normal body weight group was the lowest (1.71 ± 0.29 μg/ml), indicating a systemic inflammatory state in obesity group (Fig. 3).