CTLA4 and hepatocellular carcinoma: Owing to the relatively few cases in the HCC immunotherapy database (GSE140901), we selected three datasets with follow-up information on the treatment effect to further verify the above results, including GSE91061 (n = 39, anti-CTLA4 and anti-PD1 therapy), PRJEB25780 (n = 78, anti-PD1 therapy) and IMigor210 (n = 298, anti-PD1 therapy).