We found 7 articles related to GLP-1 RAs and cognitive impairment (see Table 2) [24–30], 5 of which were double blind, randomized, placebo-controlled trials [24, 25, 27, 28, 30], while that of Zhang et al. [26] was a randomized clinical trial and that of Li et al. [29] a prospective, parallel, open-label study. This evidence concerns the gene GLP1R and Cognitive impairment.